2021 World Series Predictions & MLB Playoffs (UPDATED)
2021 MLB Playoff Predictions
OddsSeeker Expert Picks
- For the Best Odds on the 2021 MLB Playoffs, visit BetRivers Sportsbook, but if you're in CO, check out SISportsbook.com for a $7,500 Risk-Free Bet!
- For the Best Odds on the 2021 MLB World Series Odds visit BetRivers Sportsbook and Fanduel Sportsbook
See our complete, detailed 2021 MLB Predictions in our sports betting column.
American League Favorite
Tampa Bay Rays (+250)
100-62 | AL East champs | 17.4% World Series odds
Without a single Triple Crown candidate, multiple players with 100 RBIs, or a record-setting second baseman - the Tampa Bay Rays still managed to storm their way to a 100 win season and grab the American League East division title along the way.
The Tampa Bay contingent will be relying on the sheer force of their collective will that propelled them to a centurion of victories and a league leading number of strikeouts in their quest to clinch their first-ever World Series title.
National League Favorite
San Francisco Giants (+270)
107-55 | NL West champs | 20.4% World Series odds
The San Francisco Giants have indisputably been the best show in baseball this season, and their fierce battle with the Los Angeles Dodgers for the National League West title has pushed them way past what many may have imagined being possible with their ragtag roster of underdogs, castaways, and unknowns.
Nonetheless, the Giants of San Francisco enter the 2021 MLB Playoffs among those most threatening to snatch the title from the reigning champion Dodgers.
2021 World Series Favorite
San Francisco Giants (+550) over
Bet on the best! Bet on the Giants - your 2021 MLB World Series Champions!
To bet on individual games, playoff series, league champions, and the winner of the 2021 MLB World Series visit FanDuel.
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